منابع مشابه
Taking aim at Sox18
A small molecule called Sm4 can disrupt interactions involving a transcription factor called Sox18, while having little impact on other members of the SoxF family.
متن کاملTaking aim at targets.
population: the European Prospective Investigation into Cancer in Norfolk (EPIC-Norfolk) population study. Int J Epidemiol 2004; 33: 189–198 23. Yuyun MF, Khaw KT, Luben R et al. Microalbuminuria and stroke in a British population: the European Prospective Investigation into Cancer in Norfolk (EPIC-Norfolk) population study. J Intern Med 2004; 255: 247–256 24. Harwell TS, Nelson RG, Little RR e...
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In 1854, John Snow’s work on cholera in London immortalised the power of mapping as a tool for disease prevention and control. Over 160 years later, a more ambitious effort to map cholera has been reported in The Lancet. Forgoing so-called shoe leather epidemiology in favour of big data, Justin Lessler and colleagues used 279 cholera datasets covering 2283 locations in 37 countries, and cluster...
متن کاملTaking aim at translation for tumor therapy.
Increased cap-dependent mRNA translation rates are frequently observed in human cancers. Mechanistically, many human tumors often overexpress the cap binding protein eukaryotic translation initiation factor 4E (eIF4E), leading to enhanced translation of numerous tumor-promoting genes. In this issue of the JCI, Graff and colleagues describe potent antitumor effects using second-generation antise...
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Growing on a plastic dish, the stem cells don’t look like much. Widely spaced, with jagged borders, they resemble distantly separated islands under the bright light of a microscope. But Garrett Vygantas believes cells like these could save the rhinoceros from extinction. Induced pluripotent stem (iPS) cells have the ability to mature into any type of cell in the body. Vygantas’s company, Cerato...
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ژورنال
عنوان ژورنال: eLife
سال: 2017
ISSN: 2050-084X
DOI: 10.7554/elife.24238